Science Overview

Current Method of ASD Diagnosis

Autism Spectrum Disorder (ASD) is a pervasive developmental disorder that is characterized by impairment in language and socialization as well as restricted and repetitive behavior. According to the Centers for Disease Control, the prevalence of ASD is 1 in 68 children.1

Today, ASD is diagnosed using a variety of assessments that combine direct patient observation and medical history. Developmental pediatricians and other specialists often make an ASD diagnosis after careful assessment using criteria detailed in DSM-5. In larger developmental medicine centers children are often seen by a team of experts including developmental pediatricians, speech and hearing specialists, neurologists, psychologists, psychiatrists and occupational therapists.  These teams use a variety of diagnostic tools, including DSM-5.


SynapDx Approach

Currently, there is a 2-year lag between the age of first concern and age at ASD diagnosis.2 Furthermore, physicians lack an objective test that is sufficiently informative to be clinically useful as an aid in diagnosis. Our goal is to create such a test in order to collapse the time between age of first concern and age of diagnosis.

SynapDx is developing a multi-analyte blood test that combines multiple biomarkers using proprietary algorithms into a robust test that could help physicians identify children at risk of ASD earlier than they do today. 



  1. Centers for Disease Control and Prevention (2014). Prevalence of autism spectrum disorder among children aged 8 years autism and developmental disabilities monitoring network, 11 Sites, United States, 2010. Retrieved from
  2. Rebecca E. Rosenberg, Rebecca Landa, J. Kiely Law, Elizabeth A. Stuart, and Paul A. Law, “Factors Affecting Age at Initial Autism Spectrum Disorder Diagnosis in a National Survey,” Autism Research and Treatment, vol. 2011, Article ID 874619, 11 pages, 2011. doi:10.1155/2011/874619