Publications

SynapDx Publications and Presentations:

Letovsky S, Causey ME, Aryee MJ, Skoletsky J, Proulx C, Sharp FR, Pessah IN, Hansen RL, Gregg J, Hertz-Picciotto I. Distinguishing Autism Spectrum Disorders from Other Developmental Delays Using Blood RNASeq. Poster session presented at: International Meeting for Autism Research, 2013 May 2-4; Donostia, San Sebastian, Spain. 

 

The following are many of the publications that are relevant to RNA expression and Autism Spectrum Disorders:

Hu VW, Frank BC, Heine S, Lee NH, Quackenbush J.  Gene expression profiling of lymphoblastoid cell lines from monozygotic twins discordant in severity of autism reveals differential regulation of neurologically relevant genes. BMC Genomics 18 7:118 (2006). PMID: 16709250

Hu VW, Nguyen A, Kim KS, Steinberg ME, Sarachana T, Scully MA, Soldin SJ, Luu T, Lee NH.  Gene expression profiling of lymphoblasts from autistic and nonaffected sib pairs: altered pathways in neuronal development and steroid biosynthesis. PLoS One. Jun 3; 4 (6):e5775 (2009). PMID: 19492049

Hu VW, Sarachana T, Kim KS, Nguyen A, Kulkarni S, Steinberg ME, Luu T, Lai Y, Lee NH.  Gene expression profiling differentiates autism case-controls and phenotypic variants of autism spectrum disorders: evidence for circadian rhythm dysfunction in severe autism. Autism Research  2, 78-97 (2009). PMID: 19418574

Nishimura Y, Martin CL, Vazquez-Lopez A, Spence SJ, Alvarez-Retuerto AI, Sigman M, Steindler C, Pellegrini S, Schanen NC, Warren ST, Geschwind DH.  Genome-wide expression profiling of lymphoblastoid cell lines distinguishes different forms of autism and reveals shared pathways. Human Molecular GeneticsJul 15 16 (14), 1682-98 (2007). Epub May 21, 2007. PMID: 17519220

Gregg JP, Lit L, Baron CA, Hertz-Picciotto I, Walker W, Davis RA, Croen LA, Ozonoff S, Hansen R, Pessah IN, Sharp FR.  Gene expression changes in children with autism.  Genomics. Jan 91 (1), 22-9 (2008).  Epub Nov 14, 2007. PMID: 18006270

Enstrom AM, Lit L, Onore CE, Gregg JP, Hansen RL, Pessah IN, Hertz-Picciotto I, Van de Water JA, Sharp FR, Ashwood P.  Altered gene expression and function of peripheral blood natural killer cells in children with autism.  Brain, Behavior, Immunity. Jan 23 (1), 124-33 (2009). Epub Aug 14, 2008. PMID: 18762240

Alter MD, Kharkar R, Ramsey KE, Craig DW, Melmed RD, Grebe TA, Bay RC, Ober-Reynolds S, Kirwan J, Jones JJ, Turner JB, Hen R, Stephan, DA. Autism and increased paternal age related changes in global levels of gene expression regulation. PLoS One. 2011; 6(2):e16715. Epub Feb 17, 2011. PMID: 21379579

Glatt SJ, Tsuang MT, Winn M, Chandler SD, Collins M, Lopez L, Weinfeld M, Carter C, Schork N, Pierce K, Courchesne E. Blood-based Gene Expression Signatures of Infants and Toddlers with Autism. Journal of the American Academy of Child and Adolescent Psychiatry. 51:9, 934-944e.2 (2012). PMID: 22917206

Kong SW, Collins CD, Shimizu-Motohashi Y, Holm IA, Campbell MG, Lee IH, Brewster SJ, Hanson E, Harris HK, Lowe KR, Saada A, Mora A, Madison K, Hundley R, Egan J, McCarthy J, Eran A, Galdzicki M, Rappaport L, Kunkel LM, Kohane IS. Characteristics and predictive value of blood transcriptome signature in males with autism spectrum disorders. PLoS One.  2012; 7(12):e49475. Epub Dec 5, 2012. PMID: 23227143